DOI: 10.62796/pijst.2024v1i605

  DOI URL: https://doi.org/10.62796/pijst.2024v1i605

Abstract- Literature survey on hydantoin derivatives shows various pharmacological activities, thus various hydantoin derivatives with cyclic modification of the parent structure were synthesized as possible anticonvulsant and analgesic activities. These Compounds were prepared by condensation of 3–N-p-substituted phenyl hydantoin with phenyl cyanamide to form 3-N-(psubstituted phenyl) – 1-N-(N-phenyl guanidyl) amidino hydantoin. The purity of the compounds were checked on thin layer chromatography (TLC). The compounds were analyzed for elemental analysis, the structure of compounds were characterized by Infra-red (IR) spectroscopy and nuclear magnetic spectroscopy (NMR). The compounds were screened for anticonvulsant and analgesic activities.